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Zeffix
(lamivudine)

100mg tablets

PRESCRIPTION MEDICINE

Zeffix is a novel approach to the management of chronic hepatitis B.

It is a potent inhibitor of hepatitis B virus replication. It is the first ORAL suppressive therapy for the treatment of hepatitis B with proven histologic benefit.

What are Zeffix Tablets used for?
Zeffix tablets contain lamivudine which belongs to a group of medicines called antivirals.
Zeffix is used to treat patients 16 years of age or over with long term (chronic) viral infection of the liver caused by hepatitis B. Hepatitis B is a virus which damages the liver. Treatment with Zeffix can reduce the amount of hepatitis B virus in your body. This should lead to less liver damage.
Zeffix does not reduce the risk of passing hepatitis B to others. You will still be able to pass on the hepatitis virus by sexual contact or through your blood. You should use appropriate precautions. Zeffix tablets are not addictive.
Your doctor may have prescribed Zeffix tablets for another reason. If you are already taking this medicine lamivudine for HIV infection (3TCâ„¢, Combivirâ„¢), your doctor will continue to treat you with the higher dose for that viral infection.
If you have any questions about why Zeffix tablets have been prescribed for you, ask your doctor.

How much to take
The normal adult dose is one 100 mg tablet once a day. Your doctor may prescribe a different dosage, for example if you have kidney problems. Each patient responds to the treatment differently. Your doctor will check you by taking regular blood samples. The results will help decide when you should stop taking Zeffix.

Zeffix tablets are not recommended for children under 16 years of age.

How much to take

The normal adult dose is one 100 mg tablet once a day. Your doctor may prescribe a different dosage, for example if you have kidney problems. Each patient responds to the treatment differently. Your doctor will check you by taking regular blood samples. The results will help decide when you should stop taking Zeffix

Zeffix tablets are not recommended for children under 16 years of age

How to take it

Zeffix tablets should be swallowed whole with a glass of water, and can be taken with or without food.

How long to take it

Zeffix tablets help control your condition, but do not cure it. Therefore you must take Zeffix tablets every day. Continue taking the tablets for as long as your doctor tells you to.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, then go back to taking it as you would normally.
Do not take a double dose to make up for the dose that you missed.

If you take too much (overdose)

Immediately telephone your doctor or Poisons Information Centre (03 474 7000), or go to accident and emergency at your nearest hospital, if you think you or anyone else may have taken too many Zeffix tablets. Do this even if there are no signs of discomfort or poisoning. This may need urgent medical attention. Keep telephone numbers for these places handy. If you are not sure what to do, contact your doctor or pharmacist.

Things you must do while you are taking Zeffix tablets

Tell your doctor or pharmacist that you are taking Zeffix tablets if you are about to be started on any other medicines.
Tell your doctor if you become pregnant or are trying to become pregnant.
Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.
Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily.

Things you must not do

Do not stop taking Zeffix tablets, or change the dose without first checking with your doctor. If you stop taking Zeffix your hepatitis may get worse.
This can cause serious illness particularly if your liver is already not working very well. If you do have to stop taking Zeffix your doctor is likely to arrange tests over the following four months to check how well your liver is working.
Do not give this medicine to anyone else, even if their symptoms seem similar to yours.
Do not use Zeffix tablets to treat any other complaints unless your doctor says to.

Side Effects

Check with your doctor as soon as possible if you have any health problems while taking Zeffix tablets, even if you do not think the problems are connected with the medicine or are not listed in this leaflet.
Like other medicines, Zeffix tablets can cause some side-effects. If they occur, they are most likely to be minor and temporary. However, some may be serious and need medical attention.
The most common reported side effects are:

  • Headache.
  • Vomiting and Diarrhoea.
  • Nausea.
  • Fatigue/tiredness.
  • Abdominal discomfort and pain.
  • Respiratory tract infections, throat and tonsil discomfort.
  • Dizziness.
If any of these side effects persist, or are troublesome, see your doctor. If any of the following happen, stop taking Zeffix tablets and tell your doctor immediately, or go to accident and emergency at your nearest hospital:
  • Skin troubles such as lumpy skin rash or 'hives'.
  • Swelling of the face, lips, mouth or throat which may cause difficulty in swallowing or breathing.
  • Wheezing, chest pain or tightness.
  • Fainting.
These are very serious side effects. If you have them, you may have a serious allergic reaction. You may need urgent medical attention or hospitalisation. All these side effects are very rare.

This is not a complete list of side effects.

Tell your doctor if you notice anything else that is making you feel unwell, even if it is not on this list.

Some people may get other side effects while taking Zeffix tablets. If you are concerned, talk to your doctor or pharmacist. Ask your doctor or pharmacist if you don't understand anything in this list.

Do not be alarmed by this list of possible side-effects. You may not experience any of them.

What Zeffix tablets look like
The tablets are butterscotch coloured, film-coated, capsule shaped, biconvex tablets engraved 'GX CG5' on one face. Zeffix tablets are supplied in foil blisters. The foil blisters contain 28 tablets, for oral use only, and are in a carton. Ingredients
Zeffix tablets contain 100 mg of lamivudine. Your tablets also contain the following inactive ingredients: Microcrystalline cellulose (460), magnesium stearate (572), titanium dioxide (171), hypromellose (464), sodium starch glycollate, polyethylene glycol, polysorbate 80 (433) , yellow iron oxide CI 77192 and red iron oxide CI 77491. Zeffix tablets do not contain lactose or gluten.

Do not take Zeffix if

  • Do not take Zeffix tablets if you have ever had an allergic reaction to lamivudine or any of the ingredients listed at the end of this leaflet.
  • Read the Side Effects section to find out symptoms of allergy.
  • Do not take Zeffix tablets if you are pregnant, trying to become pregnant or breastfeeding, unless your doctor says you should.
  • Your doctor will discuss the risks and benefits of using Zeffix tablets if you are pregnant or breastfeeding.
  • Do not take Zeffix tablets after the expiry or 'use by' date (EXP) printed on the pack.
  • If you take it after the expiry date has passed, it may not work as well.
  • Do not take Zeffix tablets if the packaging is torn or shows signs of tampering.
  • If you're not sure whether you should be taking Zeffix tablets, talk to your doctor.

Your doctor will tell you how many Zeffix tablets to take and how often to take them. You will also find this information on the label of your medicine. Do not take extra tablets. Do not take the tablets more often than you have been told.

Sunburn

  • Topical local anaesthetics provide immediate short-term relief.
  • Wear loose clothing to avoid irritation.
  • Drink plenty of fluids for rehydration.
  • Apply a moisturiser.
  • Have a cool bath or apply cold compresses.

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The information in CyberChemist has been prepared by New Zealand health professionals for New Zealand residents and is of a general nature only. It is NOT intended as a substitute for professional health advice for persistent or serious health problems. If in doubt please see your doctor. Disclaimer and Copyright
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